【摘 要】
：
G-protein coupled receptors (GPCRs) play an essential role in eukaryotic cells signaling.According to phylogenetic analysis,most GPCRs belong to one of four cla
【机 构】
：
National Laboratory of Macromolecules, National Center of Protein Science—Beijing, Institute of Biop
论文部分内容阅读
G-protein coupled receptors (GPCRs) play an essential role in eukaryotic cells signaling.According to phylogenetic analysis,most GPCRs belong to one of four classes,i.e.A,B,C,and Frizzled (Lagerstrom and Schioth,2008).The class-C GPCR family contains metabotropic glutamate receptors (mGluR),y-aminobutyric acid B receptors (GABAB receptor or GBR),several taste-sensing receptors (e.g.TAS1),and a Ca2+-sensing receptor (CaS).One characteristic feature of the class-C GPCRs is their dimerization,either into homo-or hetero-dimers,which is obligatory for function (Kniazeff et al.,2011).
其他文献
Nuclease-based gene editing technologies have opened up opportunities for correcting human genetic diseases.For the first time,scientists achieved targeted gene
Dear Editor,Flotillin-1 (Flot1,reggie-2) is a lipid raft-associated scaffolding protein that belongs to a family of proteins characterized by an evolutionarily
21世纪新纪元开篇,为我们描绘了美好、灿烂的明天.回首往事,不难发现,在20世纪的药物发展史上,留下了许多令人痛心的印记.rn1900年,欧美国家发现一些奇异的“蓝色人”,他们在
2000年是中国证券市场快速发展的一年。在良好的宏观经济环境和政策环境的有力推动下,随着规范化、市场化、国际化进程的日益加速,证券市场进入了新一轮的大发展时期。申银万
2011年的杭州“中华医院信息网络大会”上,《电子病历应用分级标准》首次出现在公众面前。虽然,目前这个由卫生部提议,医院管理研究所起草的标准仍然在“征求意见稿”阶段,但
Dear Editor,Prostate secretory protein 94 (PSP94), also known as β-microseminoprotein, is a product of the MSMB gene and one of the most abundant proteins foun
植物群体的生产是一个生物的输入输出系统。在这个系统中,存在着能量和物质的输入输出及其在群体各部位的分配等不同的过程。这些过程不仅直接影响
The production of a pl
The complexes of triphosphate adenosine (ATP) synthases belong to one of the most ancient protein families,and as such the complexes are ubiquitously distribute
Dear Editor,The building block of eukaryotic chromatin is the nucleosome core particle (NCP), which is consisted of ～146 bps of DNA wrapped around an octamer of
Dear Editor,Bipolar disorder (BD) is an episodic recurrent pathological mood disturbance with estimated heritability ranging from 80％-85％ (Bamett and Smoller, 200