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Dear Editor,The building block of eukaryotic chromatin is the nucleosome core particle (NCP), which is consisted of ~146 bps of DNA wrapped around an octamer of core histones.A tetramer of histone H3 and H4 and two H2A-H2B dimers form the histone octamer (Koberg, 1974;Luger et al., 1997;Thomas and Koberg, 1975).