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论述了血糖浓度变化与溶液的散射系数的关系。在浑浊介质中散射特性取决于散射粒子和溶剂的折射率的相对大小,在血液中葡萄糖浓度的改变会引起血液折射率的变化,从而使血液的散射系数发生改变,从理论上给出了血糖浓度变化时计算散射系数变化的公式,得出了散射系数和血糖浓度成正比的结论。进一步讨论了满足临床应用目标下,散射系数的相对变化的测量精度要达到4.8×10-4,而对于中国人的血液绝对测量精度要达到6.82×10-3mm-1。用双积分球实验验证了理论计算的正确性,使用牛奶作为浑浊介质测量其散射系数与糖浓度的关系,在不同波长下散射系数都随葡萄糖浓度改变而改变,且线性度可以达到0.95以上。由此可以得出结论,血糖浓度可以通过测量散射系数来得到。
The relationship between the changes of blood glucose concentration and the scattering coefficient of the solution is discussed. The scattering properties in turbid media depend on the relative sizes of the refractive indices of the scattering particles and the solvent. Changes in the concentration of glucose in the blood cause a change in the refractive index of the blood, which changes the scattering coefficient of the blood, which theoretically gives rise to the blood sugar When the concentration is changed, the formula for calculating the variation of the scattering coefficient is obtained, and the conclusion that the scattering coefficient is proportional to the blood glucose concentration is obtained. Further discussion of the clinical application of the target to meet the relative change of the scattering coefficient of measurement accuracy to reach 4.8 × 10-4, while for Chinese blood absolute measurement accuracy to reach 6.82 × 10-3mm-1. The double integral sphere experiment is used to verify the correctness of the theoretical calculation. The relationship between the scattering coefficient and the sugar concentration is measured using milk as the turbid medium. The scattering coefficients change with the glucose concentration at different wavelengths and the linearity can reach above 0.95. From this it can be concluded that the blood glucose concentration can be obtained by measuring the scattering coefficient.