Evaluation of latent links between irritable bowel syndrome and sleep quality

来源 :World Journal of Gastroenterology | 被引量 : 0次 | 上传用户:Augustin413
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AIM:To examine the links between quality of sleep and the severity of intestinal symptoms in irritable bow-el syndrome(IBS).METHODS:One hundred and forty-two outpatients(110female,32 male)who met the Rome Ⅲ criteria for IBS with no psychiatric comorbidity were consecutively en-rolled in this study.Data on age,body mass index(BMI),and a set of life-habit variables were recorded,and IBS symptoms and sleep quality were evaluated using the questionnaires IBS Symptom Severity Score(IBS-SSS)and Pittsburgh Sleep Quality Index(PSQI).The associa-tion between severity of IBS and sleep disturbances was evaluated by comparing the global IBS-SSS and PSQI score(Pearson’s correlation and Fisher’s exact test)and then analyzing the individual items of the IBS-SSS and PSQI questionnaires by a unitary bowel-sleep model based on item response theory(IRT).RESULTS:IBS-SSS ranged from mild to severe(120-470).The global PSQI score ranged from 1 to 17(median 5),and 60 patients were found to be poor sleepers(PSQI>5).The correlation between the global IBS-SSS and PSQI score indicated a weak association(r=0.2 and 95% CI:-0.03 to 0.35,P<0.05),which becomes stronger using our unitary model.Indeed,the IBS and sleep disturbances severities,estimated as latent variables,resulted significantly high intra-subject cor-relation(posterior mean of r=0.45 and 95% CI:0.17 to 0.70,P<0.05).Moreover,the correlations between patient features(age,sex,BMI,daily coffee and alcohol intake)and IBS and sleep disturbances were also ana-lyzed through our unitary model.Age was a signif icant regressor,with patients≤50 years old showing more severe bowel disturbances(posterior mean=-0.38,P<0.05)and less severe sleep disturbances(posterior mean=0.49,P<0.05)than older patients.Higher daily coffee intake was correlated with a lower sever-ity of bowel disturbances(posterior mean=-0.31,P<0.05).Sex(female)and daily alcohol intake(modest)were correlated with less severe sleep disturbances.CONCLUSION:The unitary bowel-sleep model based on IRT revealed a strong positive correlation between the severity of IBS symptoms and sleep disturbances. AIM: To examine the links between quality of sleep and the severity of intestinal symptoms in irritable bow-el syndrome (IBS). METHODS: One hundred and forty-two outpatients (110female, 32 male) who met the Rome III criteria for IBS with no psychiatric comorbidity were consecutively en-rolled in this study. Data on age, body mass index (BMI), and a set of life-habit variables were recorded, and IBS symptoms and sleep quality were evaluated using the questionnaires IBS Symptom Severity Score ( IBS-SSS) and Pittsburgh Sleep Quality Index (PSQI). The associa- tion between severity of IBS and sleep disturbances was evaluated by comparing the global IBS-SSS and PSQI score (Pearson’s correlation and Fisher’s exact test) and then analyzing the individual items of the IBS-SSS and PSQI questionnaires by a unitary bowel-sleep model based on item response theory (IRT) .RESULTS: IBS-SSS ranged from mild to severe (120-470). The global PSQI score ranged from 1 to 17 ( median 5), and 60 patients were found to be poor sleepers ( PSQI> 5) .The correlation between the global IBS-SSS and PSQI score indicated a weak association (r = 0.2 and 95% CI: -0.03 to 0.35, P <0.05), which becomes stronger using our unitary model.Indeed, the IBS and sleep disturbances severities, estimated as latent variables, resulting significantly higher high intra-subject cor-relation (posterior mean of r = 0.45 and 95% CI: 0.17 to 0.70, P <0.05) , sex, BMI, daily coffee and alcohol intake) and IBS and sleep disturbances were also ana-lyzed through our unitary model. Age was a signif icant regressor, with patients ≤50 years old more more severe bowel disturbances (posterior mean = -0.38 , P <0.05) and less severe sleep disturbances (posterior mean = 0.49, P <0.05) than older patients. Height of daily coffee intake was correlated with lower sever-ity of bowel disturbances (posterior mean = -0.31, .Sex (female) and daily alcohol intake (modest) were correlated with less severe sleep disturbances. CONCLUSION: The unitary bowel-sleep model based on IRT revealed a strong positive correlation between the severity of IBS symptoms and sleep disturbances.
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