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生存素为凋亡抑制蛋白家族新成员,具有调节细胞分裂增生和抑制细胞凋亡的双重功能,参与肿瘤的发生、发展,高表达于多种肿瘤组织,而在大多数正常成人组织中未见表达。利用生存素的这一特性,已建立了在肿瘤组织及血清中检测生存素及其抗体的许多方法,为肿瘤的诊断及治疗提供了新的有效的途径。本文就生存素及其抗体与肿瘤的诊断及治疗的国内外最新进展作一综述。
Survivin is a new member of the apoptosis-inhibitory protein family, which has the dual functions of regulating cell division and inhibiting apoptosis. It participates in the occurrence and development of tumors and is highly expressed in many tumor tissues, but not found in most normal adult tissues expression. Using this characteristic of survivin, many methods for detecting survivin and its antibody in tumor tissue and serum have been established, which provide a new and effective approach for the diagnosis and treatment of tumors. This review summarizes the latest advances in the diagnosis and treatment of survivin, its antibodies and tumors.