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探讨胃癌p53蛋白表达与胃癌生物学行为、细胞核形态、DNA含量及增殖细胞核抗原(PCNA)表达的关系。采用免疫组化S-P法、改良Feulgen染色法及图象分析技术对58例原发进展期胃癌进行p53、PCNA、DNA含量及细胞核形态检测。结果发现,p53蛋白表达与胃癌Lauren分型无关(p>0.05),而与胃癌浸润深度、淋巴结转移有关(p<0.05);p53蛋白表达阳性胃癌,癌细胞核面积大,核长径长,核周长长,PCNA 表达高,DNA指数高,DNA 2C细胞检出率低,DNA>5C检出率明显增高(p<0.05)。上述结果表明p53蛋白检测对判断胃癌浸润深度、淋巴结转移及预后有重要意义;p53蛋白表达与胃癌癌细胞核形态关系密切;p53蛋白表达阳性胃癌具有更强的增殖活性,是它发生浸润、转移的基础。
To investigate the relationship between the expression of p53 protein and the biological behavior, nuclear morphology, DNA content and the expression of proliferating cell nuclear antigen (PCNA) in gastric cancer. The immunohistochemical S-P method, modified Feulgen staining method and image analysis technique were used to detect the content of p53, PCNA, DNA and the morphology of nucleus in 58 cases of advanced gastric cancer. The results showed that p53 protein expression was not related to Lauren’s classification of gastric cancer (p> 0.05), but was related to the depth of invasion and lymph node metastasis (p <0.05); p53 protein positive gastric cancer, Long circumference, high PCNA expression, high DNA index, DNA 2C cell detection rate is low, DNA> 5C detection rate was significantly increased (p <0.05). The above results indicate that the detection of p53 protein is of great significance in determining the depth of invasion, lymph node metastasis and prognosis of gastric cancer. The expression of p53 protein is closely related to the nuclear morphology of gastric cancer cells. P53 protein positive gastric cancer has more proliferative activity, which is its infiltration and metastasis basis.