采用分光光度法研究了头孢拉定与四氯苯醌的荷移反应。以正丙醇为介质,于pH 9.00的硼砂缓冲液中,以十二烷基苯磺酸钠为增稳剂,四氯苯醌和头孢拉定形成1∶1型稳定的荷移络合物,最大吸收波长在363 nm处,线性范围为1.8×10-6~2.0×10-8mol/L,检出限为9.6×10-9mol/L。方法用于药物制剂中头孢拉定含量的测定,平均回收率为98%。 The spectrophotometric method was used to study the charge-transfer reaction between cephradine and chloranil. With n-propanol as the medium, sodium dodecylbenzenesulfonate was used as stabilizing agent in pH 9.00 borax buffer, and chloranil and cephradine formed a stable 1: 1 charge-transfer complex with the largest The absorption wavelength was at 363 nm with a linear range of 1.8 × 10-6 ~ 2.0 × 10-8 mol / L with a detection limit of 9.6 × 10-9 mol / L. Method for the determination of cefradine in pharmaceutical preparations, the average recovery was 98%.