目的　探讨新生儿胃肠穿孔的诊断和治疗方法。方法　 39例胃肠穿孔新生儿经X线、B超及腹腔穿刺等明确诊断 ,胃肠穿孔一经确诊后均采取手术治疗。结果　治愈 17例 ,死亡 2 2例 ,治愈率4 3 5 9%。死亡病例与早产低体重儿 ,延期诊断 ,误诊 ,合并感染、休克、多脏器损害等因素有关。结论　早期诊断、重视术前处理、合理选择术式及术后常规应用全静脉营养支持是提高疗效的关键。 Objective To investigate the diagnosis and treatment of gastrointestinal perforation in neonates. Methods Thirty-nine newborns with gastrointestinal perforation were diagnosed by X-ray, B-mode ultrasonography and abdominal paracentesis. The gastrointestinal perforation was diagnosed by surgery. Results cured in 17 cases, 22 cases of death, the cure rate was 4359%. Mortality and preterm low birth weight infants, delayed diagnosis, misdiagnosis, co-infection, shock, multiple organ damage and other factors. Conclusion Early diagnosis, emphasis on preoperative treatment, rational choice of surgical procedures and routine application of intravenous nutrition support is the key to improve the curative effect.