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用补肾益气活血方治疗胎儿宫内生长迟缓（ＩＵＧＲ）３０例，观察其对胎盘功能及脂质过氧化水平的影响。结果表明，孕晚期ＩＵＧＲ孕妇血清雌三醇（Ｅ３）、泌乳素（ｈＰＬ）水平均降低，而血清丙二醛（ＭＤＡ）浓度则增高，补肾益气活血方治疗组胎盘功能明显改善，Ｅ３、ｈＰＬ水平接近正常对照组，ＭＤＡ浓度与正常对照组之间无明显差异。提示脂质过氧化可能是ＩＵＧＲ发病的一个重要病理生理机制，补肾益气活血方能抗氧自由基，改善胎盘功能，促进胎儿宫内生长发育
Treatment of fetal intrauterine growth retardation (IUGR) in 30 patients with Bushen Yiqi Huoxue Decoction was conducted to observe its effect on placental function and lipid peroxidation. The results showed that the serum levels of estriol (E3) and prolactin (hPL) in IUGR pregnant women decreased during the third trimester, while the serum malondialdehyde (MDA) levels increased, and the placental function of the Bushen Yiqi Huoxue Decoction treatment group improved significantly. E3, The hPL level was close to the normal control group, and there was no significant difference between the MDA concentration and the normal control group. It is suggested that lipid peroxidation may be an important pathophysiological mechanism of the pathogenesis of IUGR. Bushenyiqihuoxue can resist oxygen free radicals, improve placental function and promote intrauterine growth and development.