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吡喹酮治疗人体包虫病的结果表明,用药剂量偏小或疗程短难以取得满意疗效;为此,我们给小白鼠胸、腹腔接种细粒棘球绦虫原头蚴,造成继发性包虫囊肿,然后应用较大剂量和较长疗程的吡喹酮进行治疗,同时对其形态上的改变作了动态观察。材料与方法细粒棘球绦虫原头蚴取自经手术完整摘除的人肺包虫囊肿,经无菌生理盐水冲洗三次后备用。选取体重12～15克的健康雌性小白鼠50只,每鼠胸、腹腔各接种1000±300个原头蚴,于接种6个月后开始给药。给药方法:50只小鼠随机分为对照组和服药组,各25只,服药组按300mg/kg/日,分二次灌胃给药,对照组给予等量溶媒(PEG400)灌胃,分别于治疗开始后4天、8天、16天、30天、60天
Praziquantel treatment of human echinococcosis results show that the dose is too small or short course of treatment is difficult to obtain satisfactory results; To this end, we give the mouse chest, abdominal cavity of echinococcus granulosus protoscoi, resulting in secondary hydatid Cysts, and then treated with larger doses and longer course of praziquantel, while its morphological changes made a dynamic observation. Materials and methods Echinococcus granulosus original cercariae taken from the complete removal of human pulmonary hydatid cysts, washed three times with sterile saline reserve. Fifty healthy female mice weighing 12-15 g were inoculated with 1000 ± 300 protoscoleces in each of the chest and abdomen. Method of administration: 50 mice were randomly divided into control group and medication group, 25 in each group. The medication group was administered by 300mg / kg / day orally, and the control group was given the same dosage of PEG400, Respectively, after the start of treatment 4 days, 8 days, 16 days, 30 days, 60 days