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目前认为氨茶减个体化给药最为合理。我们对20例哮喘急性发作的患儿(儿童哮喘18例,婴幼儿哮喘2例)全部采用个体化给药,取得较满意的效果,现报告如下。个体化给药方案的制定根据患儿的具体情况及药物动力学参数设计给药方案,使患儿的血药浓度保持在有效治疗范围之内而不引起中毒反应。按照这个原则我们应用两种方法制定个体化给药方案,一是静脉注射一次氨茶碱后,在不同的时间取血测血药浓度并求出氨茶碱的动力学参数,再用微机(电子计算机)计算出最适血药浓度(10～20μg/ml)时的口服用药
At present, the individualized administration of ammonia tea is the most reasonable. We have 20 cases of acute asthma attack in children (18 cases of asthma in children, infants and young children asthma in 2 cases) all the individual administration, and achieved more satisfactory results are as follows. The formulation of individualized dosing regimen is designed according to the specific conditions of the children and pharmacokinetic parameters to make the plasma concentration of children within the effective treatment range without causing toxic reactions. In accordance with this principle, we apply two methods to develop individualized dosing regimen. One is intravenous injection of aminophylline, blood concentration is measured at different times and the kinetic parameters of aminophylline are obtained, Computer) to calculate the optimal blood concentration (10 ~ 20μg / ml) when the oral medication