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本实验室既往工作表明电刺激腹部迷走神经中枢端引起交感神经传出兴奋,从而使血压升高和血浆血管紧张素Ⅱ增加。脑干中儿茶酚胺能通路及孤束核部分区域(闩部旁开1.5mm,向后1.0mm,深度1.5mm)参与了这一反应。 实验用猫,雌雄不限,体重2.0～3.5公斤,氨基甲酸乙酯和氯醛糖混合腹腔麻醉。气管插管,股动脲记录血压。腹部迷走神经前后两支切断后,中枢端装保护电极并用石蜡油棉球包裹,刺激参数为9.5V、0.7-1.0ms、30Hz、30秒。用江湾Ⅰ型立体定位仪固定猫头,
Previous work in our laboratory showed that electrical stimulation of the vagus nerve center of the abdomen causes sympathetic outburst, leading to increased blood pressure and increased plasma angiotensin II. The catecholaminergic pathway in the brainstem and part of the solitary tract nucleus (1.5mm next to the latch, 1.0mm posterior, 1.5mm deep) are involved in this response. Experimental cat, male or female, weighing 2.0 to 3.5 kg, urethane and chloralose mixed intraperitoneal anesthesia. Tracheal intubation, aureus urea recording blood pressure. Abdominal vagal before and after the two cut off, the central end of the protective electrode and wrapped with paraffin oil cotton balls, stimulation parameters of 9.5V, 0.7-1.0ms, 30Hz, 30 seconds. With Bay Ⅰ type stereotactic fixed cat’s head,