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选用220只雄性大鼠作一氧化碳(CO)急、慢性毒性实验。一次吸入的急性毒性实验结果表明,在616mg/m~8和102 mg/m~8组,17项观察指标中有16项出现改变;而40 mg/m~8组则只发现血红蛋白、氧合血红蛋白及血清铁略为增加,属生理范围,认为足对碳氧血红蛋白轻微增高(3.2±0.1%)的代偿反应,故确定40 mg/m~8是近似4小时作用的急性中毒阈,据此CO属高度有害物质,而按照急性毒作用带为47考虑,则属中度有害物质。慢性实验的6 mg/m~8。组,基本观察指标和卟啉代谢指标均无异常改变,因此确定CO慢性中毒阈为6mg/m~8,,慢性毒作用带为6.6,属高度有害物质。22 mg/m~8慢性毒性实验发现,实验组各项指标与对照组相比都有本质上的改变,表现为总阈值降低。耗氧量增加。红细胞和白细胞数增加,并在此之前便
220 male rats were selected as carbon monoxide (CO) acute and chronic toxicity test. Acute toxicity test results of a single inhalation showed that 16 of 17 observations changed at 616mg / m ~ 8 and 102 mg / m ~ 8, while those in 40mg / m ~ 8 showed only hemoglobin, oxygenation Hemoglobin and serum iron slightly increased, is a physiological range, that the foot of a mild increase in carboxyhemoglobin (3.2 ± 0.1%) compensatory response, it is determined 40 mg / m ~ 8 is an acute poisoning threshold of approximately 4 hours, accordingly CO is a highly hazardous substance, but according to the acute toxicity zone of 47, it is a moderately hazardous substance. Chronic experiment of 6 mg / m ~ 8. There was no abnormal change in the basic observation index and the porphyrin metabolism index. Therefore, the chronic toxicity threshold of CO was 6mg / m ~ 8 and the chronic toxicity band was 6.6, which was a highly hazardous substance. 22 mg / m ~ 8 chronic toxicity test found that the experimental group compared with the control group all the indicators have an essential change, the performance of the total threshold decreased. Oxygen consumption increased. Red blood cells and white blood cells increased, and before then