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结核性脑膜炎在世界各地仍然是可治疗的重要的传染病。诊断本病常规依据临床及肮脊液(CSF)检查。由于 CSF 镜检常找不到结核分枝轩菌,而 CSF 培养需要数周时间且敏感性差。常延误了诊断治疗,导致死亡率及发病率上升。检查结核性 CSF 中结核硬脂酸(tuberculostearic acid,TBSA)的含最是一种快速、简便、准确的方法。TBSA 是由 Anderson 等首次从结核分枝杆菌中分离出来的,为其结构成分及一些放线菌目的膜结构。正常时人体内不存在 TBSA。作者检测了22例确诊或疑诊结核性脑膜炎者的66份 CSF 标本及87例非结核性脑膜炎患者的96份 CSF
Tuberculous meningitis remains a clinically significant infectious disease in all parts of the world. Diagnosis of the disease routinely based on clinical and dirty fluid (CSF) examination. Since CSF microscopy often does not find M. tuberculosis, CSF culture takes several weeks and is less sensitive. Often delayed the diagnosis and treatment, leading to increased mortality and morbidity. Checking tuberculostearic acid (tuberculostearic acid, TBSA) in tuberculous CSF is the most rapid, simple and accurate method. TBSA was first isolated from Mycobacterium tuberculosis by Anderson, etc. for its structural components and some actinomycetes target membrane structure. Normal human TBSA does not exist. The authors tested 66 CSF samples from 22 patients with confirmed or suspected tuberculous meningitis and 96 CSF from 87 patients with non-tuberculous meningitis