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为了解白血病患者血清甲状腺激素水平的变化 ,采用放免分析方法测定 67例不同类型白血病患者血清甲状腺激素水平。结果表明急性非淋、慢粒急变及急淋患者 ,血清三碘甲状腺原氨酸 (T3)水平较正常显著降低 ,P <0 0 5,四碘甲状腺原氨酸 (T4 )水平无明显变化 ;促甲状腺激素(TSH)仅慢粒急变时较正常升高 (P <0 0 5) ,游离T4 (FT4 )急非淋及慢粒急变患者较正常降低 (P<0 0 5) ,而反三碘甲状腺原氨酸 (rT3)较正常升高 (P <0 0 1) ,急淋FT4 及rT3较正常升高 (P >0 0 5)。提示甲状腺激素水平的变化主要在急非淋及慢粒急变者 ,在急淋变化不突出。
To understand the changes in serum thyroid hormone levels in leukemia patients, radioimmunoassay was used to measure serum thyroid hormone levels in 67 patients with different types of leukemia. The results showed that serum triiodothyronine (T3) levels were significantly lower in patients with acute non-lymphocytic, acute granuloma, and acute leukorrhythmias than normal. There was no significant change in the levels of P <0 05 and tetraiodothyronine (T4). Thyroid stimulating hormone (TSH) increased more than normal at the time of CRM (P <0 05), while patients with free T4 (FT4) had an increase in acute non-lymphocytic and CRM (P <0 05). Iodine thyronine (rT3) was higher than normal (P <0 01), and acute FT4 and rT3 were higher than normal (P > 0 05). The changes of thyroid hormone levels were mainly observed in patients with acute non-lymphocytic and chronic granule changes.