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目的采用低温溶液聚合的方法,将乙酰谷酰胺在稀盐酸中聚合。方法在聚合的不同阶段,记录从投料后到粘度稳定的时间t,用纯氨中和至聚合溶液pH为7.5～8.5。结果反应中多余的盐酸对乙酰谷酰胺聚合反应体系的表观粘度、聚合物的比浓对数粘度有一定的影响。结论在聚合反应过程中除去多余的盐酸后,可以生成比浓对数粘度在2.0以上的聚合物,这对以后提高类似药品的聚合性能提供了借鉴方法。
The purpose of the method of low temperature solution polymerization, acetyl glutamine in dilute hydrochloric acid polymerization. Methods At different stages of polymerization, the time from the feeding to the stabilization of viscosity t was recorded and neutralized with pure ammonia until the pH of the polymerization solution was 7.5 to 8.5. As a result, the excess hydrochloric acid has an influence on the apparent viscosity of the acetoamide polymerization system and the inherent viscosity of the polymer. CONCLUSION: The removal of excess hydrochloric acid during the polymerization process can produce polymers with inherent viscosity of more than 2.0, which provides a reference method for improving the polymerization performance of similar drugs in the future.