用~(131)I治疗甲状腺毒症的主要副作用之一是导致甲状腺机能减退症。其发生率在第一年末是3～40%,随访10年则达70%。鉴于~(125)I电子的射程短,设想滤泡细胞核可免受辐射,随之甲状腺机能减退的发生率亦将降低。因而,有人建议以~(125)I代替~(131)I治疗甲状腺毒症,本文研究了~(131)I和~(125)I在大鼠甲状腺内放出 One of the major side effects of 131I treatment of thyrotoxicosis is hypothyroidism. Its incidence in the first year is 3 ~ 40%, up to 10 years up to 70%. Given the short range of ~ (125) I electrons, it is envisaged that the follicular cell nucleus will be protected from radiation and the incidence of hypothyroidism will also decrease. Therefore, it has been suggested that ~ (125) I can be used in the treatment of thyrotoxicosis in place of ~ (131) I. In this paper, ~ (131) I and ~ (125) I were released in the rat thyroid