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目的:观察小柴胡汤联合替普瑞酮对慢性浅表性胃炎T淋巴细胞亚群及胃黏膜COX-2表达的影响。方法:收集2015年3月~2016年3月在嘉兴市中医医院入院治疗的慢性浅表性胃炎患者106例,按入院顺序随机分为2组,对照组51例,观察组55例。比较两组患者治疗前后外周血T淋巴细胞亚群、胃黏膜COX-2表达、生活质量的影响及临床疗效。结果:与对照组比较,观察组患者外周血T淋巴细胞亚群、胃黏膜COX-2表达及生活质量显著改善,疗效显著提高,组织病理学显著改善。结论:小柴胡汤联合替普瑞酮对慢性浅表性胃炎具有良好的疗效,其机制可能与改善患者外周血T淋巴细胞亚群及胃黏膜COX-2表达有关。
Objective: To observe the effects of Xiao Chai Hu Tang combined with teprenone on the expression of COX-2 in T lymphocyte subsets and gastric mucosa of patients with chronic superficial gastritis. Methods: A total of 106 patients with chronic superficial gastritis were enrolled in Jiaxing Traditional Chinese Medicine Hospital from March 2015 to March 2016. The patients were randomly divided into two groups according to the order of admission, 51 in control group and 55 in observation group. The T lymphocyte subsets, the expression of COX-2 in gastric mucosa, the quality of life and the clinical efficacy of the two groups before and after treatment were compared. Results: Compared with the control group, the expression of COX-2 in peripheral blood and the expression of COX-2 in the gastric mucosa of the observation group were significantly improved, the curative effect was significantly improved, and the histopathology was significantly improved. Conclusion: Xiao Chai Hu decoction combined with teprenone has a good curative effect on chronic superficial gastritis. The mechanism may be related to the improvement of T lymphocyte subsets and the expression of COX-2 in gastric mucosa.