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目的:观察大剂量甲泼尼龙冲击治疗婴儿痉挛的疗效及安全性。方法:婴儿痉挛症患儿70例随机分为常规剂量组和冲击治疗组各35例。常规剂量组给予醋酸泼尼松片口服治疗;冲击治疗组治疗前5d给予甲泼尼龙冲击治疗,其后治疗方案与对照组相同。两组疗程均为8周。观察两组患儿的脑电图转归情况,临床疗效和药品不良反应,及冲击治疗对不同病因和不同病程患儿的疗效。结果:冲击治疗组总有效率为94.29%,明显高于常规剂量组的71.43%(P<0.05)。两组的脑电图转归图结果比较,差异无统计学意义(P>0.05)。冲击治疗组的不良反应发生率略高,但与常规剂量组差异不明显(P>0.05)。冲击治疗对不同病因与不同病程患儿的疗效比较,差异无统计学意义(P>0.05)。结论:大剂量甲泼尼龙冲击治疗可以有效提高婴儿痉挛患儿的临床疗效,且对安全性无明显影响。
Objective: To observe the efficacy and safety of high-dose methylprednisolone in the treatment of infantile spasms. Methods: 70 infants with infantile spasms were randomly divided into routine dose group and shock treatment group of 35 cases. The conventional dose group was treated with prednisone acetate tablets orally; the impact treatment group was treated with methylprednisolone 5 days before treatment, and then the treatment regimen was the same as that of the control group. The two groups were treated for 8 weeks. EEG status, clinical efficacy and adverse drug reactions in both groups were observed, and the curative effect of shock therapy on children with different etiologies and different durations was observed. Results: The total effective rate of shock therapy group was 94.29%, significantly higher than that of the conventional dose group (71.43%, P <0.05). There was no significant difference between the two groups (P> 0.05). The incidence of adverse reactions in the impact therapy group was slightly higher than that in the conventional dose group (P> 0.05). Impact of treatment for different causes and different duration of treatment in children, the difference was not statistically significant (P> 0.05). Conclusion: High-dose methylprednisolone impact therapy can effectively improve the clinical efficacy of infantile spasms and has no significant effect on safety.