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目的:观察三维适形放疗联合培美曲塞治疗非鳞癌局部晚期肺癌的近期疗效及毒性反应。方法:将2009年10月至2012年6月期间我院收治的非鳞癌局部晚期肺癌患者98例,将其随机分为观察组49例和对照组49例,观察组患者给予三维适形放疗联合培美曲塞进行治疗,对照组患者仅给予三维适形放疗,观察两组患者治疗的临床疗效及两组患者治疗后毒性反应的发生率。结果:两组患者经治疗后均取得一定的临床效果,观察组患者的有效率为63.3%明显高于对照组的32.7%,差异具有统计学意义(P<0.05);观察组患者毒性反应的发生率与对照组相比无显著差异(P>0.05)。结论:三维适形放疗治疗非鳞癌局部晚期肺癌时应用培美曲塞能够显著提高患者的临床疗效,且用药后的毒性反应发生率没有增加,值得在临床普遍推广与应用。
Objective: To observe the short-term curative effect and toxicity of three-dimensional conformal radiotherapy combined with pemetrexed in the treatment of locally advanced non-squamous cell lung cancer. Methods: From October 2009 to June 2012, 98 patients with locally advanced NSCLC who were treated in our hospital were randomly divided into observation group (49 cases) and control group (49 cases). Patients in the observation group were given three-dimensional conformal radiotherapy Combined pemetrexed for treatment, the control group of patients given only three-dimensional conformal radiotherapy to observe the clinical efficacy of two groups of patients treated and the incidence of post-treatment toxicity of the two groups of patients. Results: The clinical effects of both groups were obtained after treatment. The effective rate of the observation group was 63.3%, significantly higher than that of the control group (32.7%), the difference was statistically significant (P <0.05). The toxicity of the observation group There was no significant difference between the two groups (P> 0.05). Conclusion: The application of pemetrexed three-dimensional conformal radiotherapy in the treatment of locally advanced lung cancer with non-squamous cell carcinoma can significantly improve the clinical efficacy of the patients, and the incidence of toxic reactions did not increase after treatment, which is worthy of widespread application in clinic.