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目的:探讨孕妇锌水平与胎儿先天性心脏病的相关性及生化机制。方法:采用1∶1配对设计,在孕16~24周通过胎儿超声心动检查募集孕育先天性心脏病胎儿孕妇和无畸形胎儿孕妇各174例,检测孕妇全血锌、铜浓度和血清MT、CuZn SOD活力。结果:病例组的全血锌浓度、血清MT和Cu-Zn SOD活力均低于对照组,两组全血铜浓度无差异。结论:孕妇锌缺乏是先天性心脏病的原因之一,提示孕妇锌缺乏时机体的抗氧化作用减弱,胚胎心脏畸形的发生增加。
Objective: To investigate the correlation and biochemical mechanism of zinc levels in pregnant women and fetal congenital heart disease. Methods: A 1: 1 paired design was used to collect 174 pregnant and non-deformed fetal pregnant women with congenital heart disease by fetal echocardiography from 16 to 24 weeks pregnant. The levels of zinc and copper in pregnant women and serum MT and CuZn SOD vitality. Results: Whole blood zinc concentration, serum MT and Cu-Zn SOD activity in case group were lower than those in control group. There was no difference between the two groups in whole blood copper concentration. Conclusion: Zinc deficiency in pregnant women is one of the causes of congenital heart disease, suggesting that the zinc deficiency in pregnant women weakened the body’s antioxidant activity and increased the incidence of embryonic heart malformations.