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在改造促蛋白同化甾体药物的化学结构时,曾发现有些A环骈合杂环的雄甾烷,不仅有较高的促蛋白同化活性,还能明显地降低血甘油三酯与胆甾醇,并可不同程度地降低β脂蛋白,例如17α-甲基-17β-羟基-5α-雄甾烷-3-酮的A环骈合〔3,2-C〕吡唑或〔2,3-C〕呋咱,即得合成药物康力龙或去脂舒,它们已被临床用作降血脂药物。从能调整脂蛋白和降低β脂蛋白的药物来寻找降血脂新药是国外近年来研究方面之一。本文选用(±)18,19双失碳17α,13β-二
In the transformation of the chemical structure of the protein-assimilating steroid drugs, it has been found that some androstane ring A heterocyclic ring, not only has a high protein assimilation activity, but also significantly reduce the blood triglyceride and cholesterol, And may reduce, to varying degrees, beta lipoproteins, for example, A ring acenaphtho [3,2-c] pyrazole or [2,3-C ] Fuzan, that is, synthetic medicine or the lipid-Shu Kang Shu, they have been clinically used as lipid-lowering drugs. Looking for hypolipidemic drugs from drugs that can adjust lipoprotein and reduce β-lipoprotein is one of the research abroad in recent years. This article selects (±) 18,19 double-decahedra 17α, 13β-two