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恩其明(Ungeremine)是一个从(Unge-rnia minor)植物中分离而得的生物碱。我所发现其对小鼠艾氏腹水癌、L_(1210)、P_(288)、Lewis肺癌以及大鼠吉田肉瘤腹水型都有明显的抑制作用。此化合物已推荐临床试用,对中晚期卵巢癌、胃癌等有较好疗效,且副作用低,对血象、心、肝、肾等主要脏器无不良反应。鉴于恩其明(Ⅰ)是一个新类型的抗肿瘤化合物,它具有次甲基N-O-O三角和形成内铵盐结构的酚羟基和季铵基,作者曾合成了
Ungeremine is an alkaloid isolated from (Unge-rnia minor) plants. I found that it has significant inhibitory effect on Ehrlich ascites carcinoma, L 1210, P 288, Lewis lung carcinoma and ascites type of rat Yoshida sarcoma. This compound has been recommended for clinical trials, the advanced ovarian cancer, gastric cancer, etc. have a good effect, and low side effects on blood, heart, liver, kidney and other major organs without adverse reactions. Given that Enqimin (I) is a new type of antineoplastic compound that has a methine N-O-O trigonal and phenolic hydroxyl and quaternary ammonium groups that form a betaine structure, the authors have synthesized