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本文采用竞争性酶联免疫吸附法(ELISA)检测了正常大鼠、矽肺大鼠及汉防己甲素-克矽平(简称汉甲-PVNO)联合治疗的矽肺大鼠血清中抗Ⅰ型胶原抗体及抗Ⅲ型胶原抗体的存在及含量。结果表明,大鼠血清中不存在抗Ⅰ型胶原抗体。实验前三周时各组大鼠体内均存在抗Ⅲ型胶原抗体。第四周时。正常鼠血清内不再存在抗Ⅲ型胶原抗体。汉甲-PVNO治疗组大鼠血清中抗Ⅲ型胶原抗体也消失,仅矽肺大鼠血清中有抗Ⅲ型胶原抗体继续存在。
In this study, we used competitive enzyme-linked immunosorbent assay (ELISA) to detect the anti-type I collagen antibody in serum of normal rats, silicosis rats and silicosis rats treated with tetrandrine-ketopine (abbreviated as Han-PVNO). And the presence and content of anti-type III collagen antibodies. The results showed that there was no anti-type I collagen antibody in rat serum. Anti-type III collagen antibodies were present in all groups of rats in the first three weeks of the experiment. The fourth week. Anti-type III collagen antibodies are no longer present in normal mouse serum. Anti-type III collagen antibodies in the serum of rats treated with Han-PVNO also disappeared, and anti-type III collagen antibodies only persisted in the serum of silicosis rats.