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目的观察药物对14C-尿素呼吸试验(14C-UBT)的影响,为用药者选择合适的14C-UBT检查时间提供依据,以提高该试验准确性。方法对202例消化内科门诊病人进行14C-UBT,观察组(142例)检查前1月内曾有药物应用史,对照组(60例)检查前1月内未用任何药物。结果观察组HP阳性者59例,阳性率41.9%。对照组HP阳性者34例(56.6%),两组比较差异有显著性(P<0.05),1~7天用药者HP阳性率(32.1%)显著低于8~30天用药者(52.7%)(P<0.001),而8~30天的3个时段间比较差异无显著性(P>0.05),各种药物之间比较差异无显著性(P>0.05)。结论14C-UBT主要反映胃内HP的尿素酶活性,抑酸剂、铋剂、抗生素均能影响尿素酶活性而干扰14C-UBT结果,但其影响主要在检查前7天内,因此,建议7天内有上述用药史者不宜行14C-UBT。
Objective To observe the effects of drugs on 14C-UBT (14C-UBT) and to provide a basis for choosing appropriate 14C-UBT time to improve the accuracy of this test. Methods A total of 202 patients with gastroenterology outpatients underwent 14C-UBT. The patients in the observation group (142 patients) had a history of drug use within one month before the test, and the control group (60 patients) did not use any drug within one month before the test. Results In the observation group, 59 cases were positive for HP, the positive rate was 41.9%. The positive rate of HP in the control group was 34 cases (56.6%), the difference was significant between the two groups (P <0.05). The positive rate of HP in the period of 1-7 days was significantly lower (32.1% ) (P <0.001). There was no significant difference between the three time periods of 8-30 days (P> 0.05). There was no significant difference between the various drugs (P> 0.05). Conclusions 14C-UBT mainly reflects the urease activity of gastric HP. Both acid-suppressing agent, bismuth-based agent and antibiotic can affect the activity of urease and interfere with 14C-UBT. However, the main effect of 14C-UBT is within 7 days before the examination. Therefore, Have the above drug history should not be line 14C-UBT.