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目的明确白细胞介素8（IL—8）能否从牙周炎患者血清及牙周炎病变组织中检测出。方法用ELISA法检测了13例牙周正常者血清和17例牙周炎患者血清，另外还检测8例牙周炎病变组织、1例龈炎组织和1例健康牙周组织匀浆中IL—8的含量。结果健康人血清中IL—8的检出率为7．7％（1／13），牙周炎患者中血清IL—8的检出率为47％（8／17）；经X2检验，二者检出率有显著性差异（P＜0．05）；在1例龈炎组织和1例健康牙周组织中，IL—8的检出值分别为5pg／mg组织和8pg／mg组织。在大部分（6／8）牙周炎病变组织中可检测出IL—8，但有少数病变组织中难以检测出IL—8。结论IL—8参与了牙周炎的病理过程。
Objective To determine whether interleukin-8 (IL-8) can be detected from the serum of periodontitis patients and the periodontitis tissues. Methods Thirteen cases of periodontal normal serum and 17 cases of periodontitis serum were detected by ELISA. In addition, 8 cases of periodontitis, 1 case of gingivitis and 1 case of healthy periodontal tissue were also detected for IL- 8 content. Results The detection rate of serum IL-8 in healthy volunteers was 7.7% (1/13), while the detection rate of IL-8 in periodontitis patients was 47% (8/17). After X2 test, (P <0.05). In one gingivitis tissue and one healthy periodontal tissue, the detection values of IL-8 were 5pg / mg tissue and 8pg / mg tissue, respectively. IL-8 was detectable in most (6/8) periodontitis lesions, but it was difficult to detect IL-8 in a few lesions. Conclusion IL-8 is involved in the pathological process of periodontitis.