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目的:分析HIV阳性的海洛因依赖者戒毒前后(120天)CD4+T细胞的变化趋势,探讨戒毒对免疫功能的影响。方法:共有HIV阳性海洛因依赖者19例和同期HIV阴性海洛因依赖者25例入选本项研究。在入所7天内及戒毒120天后两次采集外周血,经流式细胞仪进行CD4+T细胞检测计数,SPSS11.5软件包统计分析。结果:HIV阳性与阴性者CD4+T细胞计数均值差异显著,HIV阳性的海洛因依赖者入所时CD4+T细胞计数值多数低于450×106/L,也有部分高于450×106/L。HIV阴性的海洛因依赖者CD4+T细胞计数均值戒毒后轻微下降。HIV阳性者CD4+T细胞计数均值戒毒后轻微上升,但两组间戒毒前后差值无统计学意义,组内CD4+T细胞计数戒毒前后无统计学差异。HIV阳性,且入所时CD4+T细胞值低于450×106/L的海洛因依赖者,戒毒120天后CD4+T细胞计数值显著上升,戒毒前后计数配对t检验,P﹤0.01,差异高度显著。结论:海洛因依赖合并HIV感染且已表现免疫功能受损者戒毒有助于其CD4+T细胞回升,从而延缓艾滋病发病。
Objective: To analyze the trend of CD4 + T cells in HIV-positive heroin addicts before and after treatment (120 days), and to explore the effect of detoxification on immune function. Methods: A total of 19 HIV-positive heroin addicts and 25 HIV-negative heroin addicts during the same period were enrolled in this study. Peripheral blood samples were collected twice within 7 days of admission and 120 days after drug treatment. CD4 + T cell counts were counted by flow cytometry and SPSS11.5 software package was used for statistical analysis. Results: There was significant difference in mean CD4 + T cell counts between HIV positive and negative subjects. Most HIV positive heroin addicts had CD4 + T cell counts less than 450 × 106 / L at admission and some were higher than 450 × 106 / L. The mean CD4 + T cell count in HIV-negative heroin addicts decreased slightly after detoxification. The mean of CD4 + T cell count in HIV-positive patients increased slightly after detoxification, but there was no significant difference between the two groups before and after detoxification. There was no significant difference in CD4 + T cell count before and after detoxification. HIV positive, and the admission of CD4 + T cell values below 450 × 106 / L of heroin addicts, after 120 days of drug treatment, CD4 + T cell counts increased significantly, before and after treatment count paired t test, P <0.01, the difference was highly significant. CONCLUSIONS: Heroin dependence with HIV infection and detoxification of those with impaired immune function contribute to the recovery of CD4 + T cells, thus delaying the onset of AIDS.