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恶性肿瘤的早期诊断以及特异性药物的应用,已证实可以延长众多恶性肿瘤患者的中位生存期。然而,由于许多药物的药代动力学欠佳,在全身给药时常迅速失活,甚至无法到达肿瘤灶。基于对肿瘤组织的趋向性,基因修饰的间充质干细胞提供了一种颇具潜力的投送药物的细胞载体。随着恶性肿瘤的快速进展,肿瘤的间质微环境被激活并进一步促进肿瘤进展。因此,同时靶向肿瘤细胞及其微环境的新型肿瘤治疗策略可能为恶性肿瘤的治疗提供新的机遇。
Early diagnosis of malignant tumors and the use of specific drugs have been shown to prolong the median survival of many malignancies. However, due to the poor pharmacokinetics of many drugs, systemic injections are often rapidly inactivated and can not even reach the tumor site. Based on the tendency to tumor tissue, genetically modified mesenchymal stem cells provide a promising drug delivery cell carrier. With the rapid progress of malignant tumors, the tumor interstitial microenvironment is activated and further promote tumor progression. Therefore, novel tumor therapy strategies targeting both tumor cells and their microenvironment may provide new opportunities for the treatment of malignant tumors.