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[目的]检测各型肝脏疾病患者血清中前白蛋白(PA)、转铁蛋白(Tf)、白蛋白(ALB)的含量变化,同时与健康组比较,观察其在肝病诊断中的应用价值。[方法]用免疫透射比浊法测定血清中PA、Tf的含量,用溴甲酚绿法测定ALB的含量。[结果]各型肝病与各项血清学指标之间存在一定的相关性,但各指标的灵敏度不同,各项血清学指标灵敏度PA﹥Tf﹥ALB;各型肝病血清PA含量与健康组比较均减低,其血清PA含量降低程度重症肝炎﹥肝癌﹥肝硬化﹥慢性轻、中度肝炎﹥急性黄疸型肝炎。[结论]血清PA浓度是观察肝脏损伤和评价受损程度的一项敏感指标,为临床对肝脏疾病的诊断、治疗以及预后判断提供了重要依据,具有较高的临床应用价值。
[Objective] To detect the changes of serum albumin (PA), transferrin (Tf) and albumin (ALB) in patients with various types of liver diseases and to compare their clinical value with healthy people in the diagnosis of liver diseases. [Method] The contents of PA and Tf in serum were determined by immunoturbidimetry and the content of ALB was measured by bromocresol green method. [Results] There were some correlations between various liver diseases and various serological indexes, but the sensitivity of each index was different. The sensitivity of each serological index was PA> Tf> ALB. Reduce the level of serum PA reduced the degree of severe hepatitis> liver cancer> cirrhosis> chronic mild to moderate hepatitis> acute jaundice hepatitis. [Conclusion] Serum PA concentration is a sensitive index for observing liver damage and evaluating the degree of damage. It provides an important basis for clinical diagnosis, treatment and prognosis of liver diseases and has high clinical value.