虹膜—角膜内皮综合征(ICE综合征)是涉及单眼为主,以青光眼、角膜内皮增殖和虹膜基质异常为表现的一组疾病。1903年,Harms首先描述了一种单眼青光眼和广泛虹膜萎缩的病变,命名为“原发性进行性虹膜萎缩”I。1956年Chandler报道了一组类似的病例,所不同在于其有角膜水肿和角膜内皮营养不良,而虹膜萎缩轻微,且仅限于虹膜基质,称为“Chandler氏综合征”。1969等Cogan和Reese描述了 Iris - corneal endothelium syndrome (ICE syndrome) is a group of diseases that are predominantly monocular, manifesting as glaucoma, corneal endothelial proliferation, and iris stromal abnormalities. In 1903, Harms first described a disease of monocular glaucoma and extensive atrophy of the iris, termed “primary progressive iris atrophy”. In 1956 Chandler reported a similar group of cases, the difference is that it has corneal edema and corneal endothelial malnutrition, and Iris atrophy, and limited to the iris stroma, known as “Chandler’s syndrome.” 1969 etc Cogan and Reese described