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将59例合并早期DN的T2DM患者随机分为给予缬沙坦(A组)、五苓胶囊联合缬沙坦(B组)治疗3个月,观察治疗前后平均动脉压(MAP)、空腹血糖(FPG)、糖化血红蛋白(HbA1c)、尿白蛋白排出率(UAER)、血脂(TC、TG、HDL-C、LDL-c)、等。结果 2组UAER均有下降,B组显著(P<0.01),低于A组(P<0.05);B组的TC、LDL-c、TG、红细胞聚集指数、全血高切粘度、全血低切粘度、血浆比粘度、纤维蛋白原及血沉较治疗前下降(P<0.05)。结论五苓胶囊和缬沙坦联合治疗有调整脂代谢,减少蛋白尿,改善血液流变学,肾脏保护作用。
Fifty-nine T2DM patients with early DN were randomly divided into three groups: valsartan (group A), Wuling capsules combined with valsartan (group B) for 3 months. Mean arterial pressure (MAP), fasting plasma glucose FPG, HbA1c, UAER, lipids (TC, TG, HDL-C and LDL-c), and so on. Results The levels of UAER decreased in both groups (P <0.01), but lower than those in group A (P <0.05). The levels of TC, LDL-c, TG, erythrocyte aggregation index, Low shear viscosity, plasma specific viscosity, fibrinogen and erythrocyte sedimentation rate decreased before treatment (P <0.05). Conclusion Wuling Capsule and valsartan combined therapy can regulate lipid metabolism, reduce proteinuria, improve blood rheology, renal protection.