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目的:通过回顾性分析103例非小细胞肺癌(non-small cell lung cancer,NSCLC)患者,了解胸腔镜下肺癌根治术后患者的临床特点及影响预后的因素。方法:随访南京医科大学第一附属医院103例NSCLC胸腔镜下肺癌根治术后患者,应用χ2检验、Log-rank检验、Cox回归分析相关临床资料。结果:103例NSCLC患者的平均年龄(61.5±9.4)岁,男性多见(75.7%);腺癌为主(60.2%);Ⅰ、Ⅱ期最多(70.9%);总体1、3、5年生存率分别为96.1%、77.0%和67.3%;术前合并慢性阻塞性肺病(chronic obstructive pulmonary disease,COPD)的肺癌患者1、3、5年生存率分别为94.1%、47.1%和40.3%,不合并COPD的肺癌患者1、3、5年生存率分别为96.5%、86.0%和72.6%;Log-rank检验分析结果显示,术前合并COPD与不合并COPD组患者生存情况差异具有统计学意义(P<0.05)。结论:NSCLC胸腔镜下肺癌根治术患者以男性居多,腺癌为主,绝大多数有吸烟史。Ⅰ期患者5年生存率为76.0%,术前合并COPD是影响NSCLC胸腔镜下肺癌根治术后预后的因素之一。
Objective: To retrospectively analyze 103 patients with non-small cell lung cancer (NSCLC) and to investigate the clinical characteristics and prognostic factors of patients undergoing thoracoscopic radical resection of lung cancer. Methods: Follow-up was performed in 103 NSCLC patients undergoing thoracoscopic radical resection of lung cancer at First Affiliated Hospital of Nanjing Medical University. Chi-square test, Log-rank test and Cox regression were used to analyze the clinical data. Results: The average age of 103 NSCLC patients was (61.5 ± 9.4) years old, more common in men (75.7%), adenocarcinoma (60.2%), highest in stage Ⅰ and Ⅱ (70.9%), The survival rates were 96.1%, 77.0% and 67.3% respectively. The 1, 3, 5-year survival rates of lung cancer patients with preoperative pulmonary obstructive pulmonary disease (COPD) were 94.1%, 47.1% and 40.3% The 1, 3, 5-year survival rates of lung cancer patients without COPD were 96.5%, 86.0% and 72.6%, respectively. Log-rank test showed that there was significant difference in survival between preoperative COPD and non-COPD patients (P <0.05). Conclusion: There are mostly male patients and adenocarcinomas in NSCLC undergoing thoracoscopic radical resection of lung cancer. Most of them have a history of smoking. The 5-year survival rate of stage Ⅰ patients is 76.0%. Preoperative combined with COPD is one of the factors influencing the prognosis of lung cancer undergoing thoracoscopic surgery after NSCLC.