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目的:观察桑椹多糖对链脲佐菌素(STZ)和高能量饲料诱发的2型糖尿病(T2DM)模型大鼠血糖、血脂的影响。方法:高糖高脂饲料喂养4周后,ip 30 mg·kg-1STZ建立T2DM大鼠模型,随机分为糖尿病模型对照组、桑椹多糖低剂量组(ig150 mg·kg-1·d-1)、中剂量组(ig 300 mg·kg-1·d-1)、高剂量组(ig 450 mg·kg-1·d-1)及罗格列酮治疗组(ig 4 mg·kg-1·d-1)。持续ig给药60 d后测空腹血糖(FBG)、血脂、糖化血红蛋白(HbAlc)、胰岛素(Ins)的含量。结果:桑椹多糖治疗组与模型组比较,FBG,HbAlc,甘油三酯(TG)、总胆固醇(TCH)及低密度脂蛋白(LDL)水平显著降低(P<0.05),高密度脂蛋白(HDL)和Ins水平显著升高(P<0.05)。结论:桑椹多糖能有效地降低T2DM模型大鼠的血糖,促进Ins分泌,调节血脂。
Objective: To observe the effect of mulberry polysaccharide on blood glucose and blood lipids in streptozotocin (STZ) and high-energy diet-induced type 2 diabetes mellitus (T2DM) rats. Methods: After being fed with high-fat and high-fat diet for 4 weeks, T2DM rat model was established by ip 30 mg · kg-1STZ and randomly divided into diabetic model control group, mulberry polysaccharide low-dose group (ig150 mg · kg-1 · d- , Middle dose group (ig 300 mg · kg -1 · d -1), high dose group (ig 450 mg · kg -1 · d -1) and rosiglitazone treatment group (ig 4 mg · kg -1 d-1). The levels of fasting blood glucose (FBG), lipids, HbAlc, and Ins were measured after 60 days of administration. Results: Compared with the model group, the levels of FBG, HbAlc, triglyceride (TG), total cholesterol (TCH) and low density lipoprotein (LDL) in the mulberry polysaccharide group were significantly decreased (P < ) And Ins levels were significantly increased (P <0.05). Conclusion: Mulberry polysaccharide can effectively reduce blood glucose in T2DM rats, promote the secretion of Ins and regulate the blood fat.