Objective:To investigate the prognostic influence on long-term overall survival(OS) from treatment with Chinese medicine(CM) and chemotherapy or targeted therapy in advanced non-small-cell lung cancer(NSCLC) patients.Methods:The clinical data of 206 advanced NSCLC patients who were treated with CM and Western medicine in Beijing Cancer Hospital from April 1999 to July 2013 were retrospectively analyzed.Long-term survivors were defined as OS > 3 years after treatment with CM and chemotherapy.Twenty-eight patients had OS > 3 years,178 had OS < 3 years,and all clinical data were statistically analyzed with the Cox model.Variables were gender,age,smoking status,performance status(PS) score,pathological type,clinical stage,first-line chemotherapy,targeted therapy,and use of CM.Univariate survival analysis was performed using the Kaplan-Meier method and log-rank sequential inspection.Multivariate survival analysis was used to analyze the meaningful factors of univariate survival analysis with the Cox model.Results:The survival rate of patients with OS > 3 years was 13.6%(28/206).Cox multivariate regression analysis showed that PS score,clinical stage,disease control rate to first-line chemotherapy,and use of CM were independent factors of longterm OS(all P<0.05).However,gender,age,smoking,and use of epidermal growth factor receptor tyrosinekinase inhibitor were not significant(P>0.05).Conclusion:PS score,clinical stage,disease control rate to firstline chemotherapy,and use of CM are probably independent prognostic factors for long-term OS in patients with advanced NSCLC. Objective: To investigate the prognostic influence on long-term overall survival (OS) from treatment with Chinese medicine (CM) and chemotherapy or targeted therapy in advanced non-small-cell lung cancer (NSCLC) patients. Methods: The clinical data of 206 advanced-NSCLC patients who were treated with CM and Western medicine in Beijing Cancer Hospital from April 1999 to July 2013 were retrospectively analyzed. Long-term survivors were defined as OS> 3 years after treatment with CM and chemotherapy. Twenty-eight patients had OS> 3 years, 178 had OS <3 years, and all clinical data were being analyzed with the Cox model. Variables were gender, age, smoking status, performance status (PS) score, pathological type, clinical stage, first-line chemotherapy, targeted therapy, and use of CM. Univariate survival analysis was performed using the Kaplan-Meier method and log-rank sequential inspection. Multivariate survival analysis was used to analyze the meaningful factors of univariate survival analysis wit h the Cox model. Results: The survival rate of patients with OS> 3 years was 13.6% (28/206). Cox multivariate regression analysis showed that PS score, clinical stage, disease control rate to first-line chemotherapy, and use of Gender, age, smoking, and use of epidermal growth factor receptor tyrosine kinase inhibitor were not significant (P> 0.05) .Conclusion: PS score, clinical stage, disease control rate to firstline chemotherapy, and use of CM are probably independent prognostic factors for long-term OS in patients with advanced NSCLC.