不影响正常人的刺激物所引起的可逆性气管阻塞,迅速发展并持续是“哮喘”患者肺功能紊乱的主要原因。此病的其它症状例如易引起刺激、气管阻塞的分布、炎症的出现、上皮和腺体的分泌异常以及对治疗的效应等,在病人中有很大的差别。因之,化学介体的致病作用,肺的神经性影响的不平衡,以及在保持气管高度敏感的许多其它因素方面,病人也有差异。虽然典型哮喘的病因和表现不尽相同,但Hardy及其同事在本期杂志的另篇文章中清楚地阐明了气管过敏的另一特征。在有哮喘而无气管阻塞的中度变态反应型青年患者,吸 Reversible tracheal obstruction, which does not affect normal human stimuli, rapidly develops and persists as a major cause of pulmonary dysfunction in “asthma” patients. Other symptoms of the disease, such as predisposition to irritation, distribution of tracheal obstruction, the appearance of inflammation, abnormal secretion of epithelium and gland, and effects on treatment, are very different in patients. As a result, the pathogenic effects of chemical mediators, the imbalance of the neurogenic effects of the lungs, and many other factors that keep the trachea highly sensitive are also different. Although the causes and manifestations of typical asthma vary, Hardy and colleagues clearly identified another tracheal hypersensitivity feature in another article in this issue of the journal. In moderate asthma without asthma in patients with moderate obstruction of young patients, sucked