论文部分内容阅读
目的探讨苯那普利联合氯沙坦治疗高血压的疗效。方法选取2010年1月—2014年6月保定市骨科医院收治的原发性高血压患者125例,采用抽签法将患者分为苯那普利组(42例)、氯沙坦组(37例)和联合治疗组(46例)。苯那普利组患者予以苯那普利治疗;氯沙坦组患者予以氯沙坦治疗;联合治疗组患者予以苯那普利联合氯沙坦治疗。观察3组患者治疗前后血压(收缩压、舒张压)、肾功能〔尿微量清蛋白(MAU)、血肌酐(Scr)、血尿酸(SUA)〕及不良反应发生情况。结果治疗前3组患者收缩压、舒张压、MAU、Scr、SUA比较,差异无统计学意义(P>0.05);治疗后3组收缩压、舒张压、MAU、Scr、SUA比较,差异有统计学意义(P<0.05);联合治疗组患者收缩压、舒张压、Scr低于苯那普利组和氯沙坦组,差异有统计学意义(P<0.05);苯那普利组和联合治疗组患者MAU低于氯沙坦组,氯沙坦组和联合治疗组患者SUA低于苯那普利组,差异有统计学意义(P<0.05);3组患者不良反应发生率比较,差异有统计学意义(P<0.05);苯那普利组干咳和血钾升高发生率高于氯沙坦组和联合治疗组,差异有统计学意义(P<0.05)。结论苯那普利联合氯沙坦治疗高血压的疗效显著,可改善患者肾功能,且不良反应小。
Objective To investigate the efficacy of benazepril combined with losartan in the treatment of hypertension. Methods From January 2010 to June 2014, 125 patients with essential hypertension admitted to orthopedic hospital of Baoding were enrolled. Patients were divided into benazepril group (n = 42), losartan group (n = 37) ) And combination therapy group (46 cases). The benazepril group was treated with benazepril, the losartan group with losartan was given, and the benazepril combined with losartan was given to the combination therapy group. The blood pressure (systolic blood pressure, diastolic blood pressure), renal function (MAU, Scr, SUA) and adverse reactions in the three groups were observed before and after treatment. Results There was no significant difference in systolic blood pressure, diastolic blood pressure, MAU, Scr and SUA between the three groups before treatment (P> 0.05). There was statistical difference in systolic blood pressure, diastolic blood pressure, MAU, Scr and SUA (P <0.05). The systolic blood pressure, diastolic blood pressure and Scr in the combined treatment group were lower than those in the benazepril group and the losartan group (P <0.05). The benazepril group and the combination The SUA in the treatment group was lower than that in the losartan group, losartan group and combination therapy group, and the difference was statistically significant (P0.05) (P <0.05). The incidence of dry cough and serum potassium in benazepril group was higher than that in losartan group and combination therapy group (P <0.05). Conclusion Benazepril combined with losartan in the treatment of hypertension has significant curative effect, which can improve renal function and reduce adverse reactions.