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目的探讨高尿酸血症与代谢综合征之间的相关性。方法以2009年在天津市和平区健康指导中心参加体检的21014名企事业职工为调查对象,进行血尿酸、体质指数、血糖、血压、总胆固醇、甘油三酯、高密度脂蛋白胆固醇的检测。采用单因素和多因素Logistic回归分析代谢综合征各组分与高尿酸血症的发生关系,应用χ2检验进行患病率的比较,应用方差分析进行均数的比较。结果调查对象中男性组代谢综合征、高尿酸血症、代谢综合征合并高尿酸血症患病率分别为21.7%、16.3%、4.8%;女性组各指标分别为14.3%、9.5%、3.4%,男性组患病率均高于女性组,差异有统计学意义(P<0.01)。人群所患随代谢综合征诊断标准中不同诊断项目疾病种类的增加,其血尿酸值随之增大,差异有统计学意义(F=3537.199,P<0.01),高尿酸血症的患病率也出现明显上升趋势(χ2=1022.413,P<0.01)。高尿酸血症组超重(肥胖)、高血糖、高血压、血脂异常患病率分别为65.8%、29.3%、43.8%、55.9%,正常血尿酸组各指标分别为40.2%、19.6%、28.3%、28.4%,高尿酸血症组患病率均高于正常血尿酸组,差异有统计学意义(P<0.01)。多因素Logistic回归分析结果显示,超重(肥胖)(OR=1.987,95%CI=1.811～2.180)、高血糖(OR=1.116,95%CI=1.011～1.232)、高血压(OR=1.250,95%CI=1.138～1.373)、血脂异常(OR=2.355,95%CI=2.155～2.573)均增加了高尿酸血症的发生风险。结论高尿酸血症与代谢综合征及其各组分具有相关性,及早防治高尿酸血症及代谢综合征具有重要意义。
Objective To investigate the correlation between hyperuricemia and metabolic syndrome. Methods A total of 21,014 employees who participated in the physical examination in Tianjin Heping District Health Guidance Center in 2009 were investigated. Serum uric acid, body mass index, blood glucose, blood pressure, total cholesterol, triglyceride and high density lipoprotein cholesterol were measured. Univariate and multivariate logistic regression analysis was used to analyze the relationship between the components of metabolic syndrome and the incidence of hyperuricemia. Chi-square test was used to compare the prevalence and the mean was compared using ANOVA. Results The prevalence rates of metabolic syndrome, hyperuricemia and metabolic syndrome with hyperuricemia were 21.7%, 16.3% and 4.8% respectively in male subjects and 14.3%, 9.5% and 3.4% in female subjects respectively %, Male patients were higher than the prevalence of the female group, the difference was statistically significant (P <0.01). The prevalence of blood uric acid increased with the increase of different diagnostic items in the diagnostic criteria of the metabolic syndrome in the population. The difference was statistically significant (F = 3537.199, P <0.01). The prevalence of hyperuricemia Also showed a clear upward trend (χ2 = 1022.413, P <0.01). The prevalences of overweight (obesity), hyperglycemia, hypertension and dyslipidemia in hyperuricemia group were 65.8%, 29.3%, 43.8% and 55.9%, respectively, and those in normal uric acid group were 40.2%, 19.6% and 28.3 %, 28.4% respectively. The prevalence of hyperuricemia group was higher than that of normal uric acid group (P <0.01). Multivariate logistic regression analysis showed that overweight (OR = 1.987, 95% CI = 1.811-2.180), hyperglycemia (OR = 1.116, 95% CI = 1.011-1.232), hypertension (OR = 1.250, % CI = 1.138-1.373), dyslipidemia (OR = 2.355, 95% CI = 2.155-2.573) increased the risk of hyperuricemia. Conclusions Hyperuricemia is related to metabolic syndrome and its components, and it is of great significance to prevent and treat hyperuricemia and metabolic syndrome as soon as possible.