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本文用不饱和脂肪酸治疗脓毒症大鼠,观察治疗前、后大鼠血浆TXB2、6-酮-PGF1α、PGE2及肝脏枯否氏细胞膜、红细胞膜花生四烯酸(AA)水平的变化,并探讨其机理。结果表明脓毒症大鼠血浆三种AA代谢产物水平明显高于正常组(P<0.01);枯否氏细胞膜和红细胞膜的AA含量明显降低(P分别<0.01和<0.05)。经富含不饱和脂肪酸的鱼油治疗后,血浆TXB2、PGE2明显降低,两种细胞膜AA含量明显升高(P<0.01)。但血浆6-酮-PGF1α仍处于高水平状态。提示在炎性反应时细胞膜AA发生明显变化,而肠道给予不饱和脂肪酸,可以改变膜AA含量,减少炎症介质的产生。
In this paper, unsaturated fatty acid treatment of septic rats, observed before and after treatment in rats plasma TXB2, 6-keto-PGF1α, PGE2 and Kupffer cell membrane, erythrocyte membrane arachidonic acid (AA) levels and Explore its mechanism. The results showed that the levels of three AA metabolites in plasma of septic rats were significantly higher than those in normal rats (P <0.01). The AA content in the plasma membrane and erythrocyte membrane of Kupffer cells was significantly decreased (P <0.01 and <0, respectively). 05). After treatment with fish oil rich in unsaturated fatty acids, plasma TXB2 and PGE2 were significantly decreased, AA content of both cell membrane was significantly increased (P <0.01). However, plasma 6-keto-PGF1α is still at a high level. Prompt inflammatory response in the cell membrane AA significant changes, while the intestinal administration of unsaturated fatty acids, can change the membrane AA content, reduce the production of inflammatory mediators.