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目的分析高危孕妇孕中期羊水细胞胎儿染色体结果。方法 2009年1月至2013年7月宁波地区8446位有产前诊断指征的孕妇抽取羊水进行细胞遗传学分析。结果 8446例羊水细胞共检出胎儿异常染色体核型187例,检出率为2.21%。其中染色体数目异常为137例,结构异常38例,嵌合体12例。结论对高危孕妇开展产前诊断可以有效降低出生缺陷率。
Objective To analyze the chromosomal results of the fetuses with amniotic fluid in the second trimester of high risk pregnancy. Methods From January 2009 to July 2013, 8446 pregnant women with prenatal diagnosis indications in Ningbo area were drawn to carry out cytogenetic analysis. Results A total of 187 cases of fetal abnormal chromosome karyotype were detected in 8 446 cases of amniotic fluid cells, the detection rate was 2.21%. Among them, there were 137 abnormal chromosomes, 38 abnormal structures and 12 chimeras. Conclusion Prenatal diagnosis of high-risk pregnant women can effectively reduce the birth defect rate.