血管内皮生长因子(vascular endothelial growthfactor,VEGF)又称血管通透性因子(vascular perme-ability factor,VPF)或血管调理素(vasculotropin),是一组功能强大且能产生多种效应的细胞因子[1]。1989年Ferrara[2]等从牛垂体滤泡星状细胞体外培养液中首先分离纯化出来的一类 Vascular endothelial growth factor (VEGF), also known as vascular perme-ability factor (VPF) or vasculotropin, is a group of powerful and can produce a variety of effects of cytokines [ 1]. 1989 Ferrara [2] and so on from the bovine pituitary vesicular stellate cells in vitro culture medium first isolated and purified