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特发性血小板减少性紫癜(ITP)发生在儿童时,对什么病例需予治疗、何时给予治疗以及采用何种治疗最为合适等,都是有待深入讨论的问题。本文对 ITP 的自然史、病理生理学、治疗方案的选择,尤其对一些有争议的看法进行了复习和讨论。儿童中的 ITP 是一种比较良性的疾病。此病常因广泛的出血症状、血小板计数低于2万/ml,甚或低于1万/ml 而作出诊断。出血非常严重的病例(如颅内出血),其发生率不足1%。再者,出血即使累及中枢神经系统,有些病人仍能存活而并不遗下严重的神经后遗症。约有85%的儿童在诊断确定后的6—12个月内可以完全恢复或病情明显改善而毋需再作
Idiopathic thrombocytopenic purpura (ITP) occurs in children, what cases need treatment, when to give the treatment and the treatment is the most appropriate and so on, are the issues to be further discussed. This review and discussion of ITP’s natural history, pathophysiology, treatment options, and in particular, some controversial views. ITP in children is a more benign condition. This disease is often diagnosed due to extensive bleeding symptoms, with platelet counts below 20,000, or even below 10,000. Very serious bleeding cases (such as intracranial hemorrhage), the incidence of less than 1%. Furthermore, even with bleeding that affects the central nervous system, some patients survive without serious neurological sequelae. Approximately 85% of children recover completely within 6-12 months of diagnosis or have their condition significantly improved without further work