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第一代抗抑郁药——三环类药物问世30年来,在抗抑郁治疗中疗效确切。但是这类药物副作用甚多,不仅常见有口渴、视力模糊等抗交感副作用,尤其锥体外系症状及心肌损害、循环系统的低血压等不良反应较重,而且使老年青光眼、前列腺肥大患者用药受到限制。近十年来出现的与三环类化学结构完全不构的第二代抗抑郁药,抗抑郁作用快,不良反应相对减少,已被广泛引起重视,应用于临床。
The first generation of antidepressants - Tricyclic drugs come out 30 years ago, the antidepressant treatment in the exact effect. However, many side effects of these drugs, not only common thirst, blurred vision and other anti-sympathetic side effects, in particular extrapyramidal symptoms and myocardial damage, circulatory system hypotension and other adverse reactions heavier, but also the elderly glaucoma, prostatic hypertrophy patients medication restricted. The second generation antidepressants which have not been completely conformed to the tricyclic chemical structure appeared in the past ten years have been widely used in clinic because of their antidepressant effect and relative adverse reactions.