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目的了解解脲支原体(Uu),人型支原体(Mh)的感染状况及其常用治疗药物的体外敏感性,指导临床合理用药。方法应用Mycoplasma IST试剂盒进行支原体检测及药敏分析。结果1023例疑似非淋菌性尿道炎(NGU)患者中357例支原体培养阳性,阳性率为34.9%;其中Uu阳性257例(阳性率为25.1%),Uu+Mh阳性91例(阳性率为8.9%),Mh阳性9例(阳性率为0.9%)。对环丙沙星的耐药率最高,占68.0%;其次为氧氟沙星和红霉素,分别为58.0%和50.9%;对司帕沙星、左氧氟沙星、四环素、美满霉素、罗红霉素、多西环素、克拉霉素、阿奇霉素、交沙霉素的耐药率分别为38.1%,31.5%,10.1%,5.1%,4.7%,4.3%,3.1%,2.7%,0.8%。结论加强支原体的药敏检测,根据药敏结果合理用药,对防止支原体耐药株产生具有重要意义。
Objective To understand the infection status of Uu and Mh and the in vitro sensitivity of commonly used therapeutic drugs to guide clinical rational drug use. Methods Mycoplasma IST kit was used for mycoplasma detection and drug susceptibility analysis. Results Of the 1023 patients with suspected non-gonococcal urethritis (NGU), 357 cases of mycoplasma were positive for culture, with a positive rate of 34.9%. There were 257 Uu positives (positive rate was 25.1%) and 91 Uu + Mh positives (positive rate 8.9% %), Mh positive in 9 cases (positive rate of 0.9%). The drug resistance rates to ciprofloxacin were the highest, accounting for 68.0%; followed by ofloxacin and erythromycin, respectively, 58.0% and 50.9%; sparfloxacin, levofloxacin, tetracycline, minocycline, The resistance rate of the three isolates was 38.1%, 31.5%, 10.1%, 5.1%, 4.7%, 4.3%, 3.1%, 2.7% and 0.8% . Conclusion Strengthening mycoplasma sensitivity test, according to drug susceptibility results rational use of drugs, to prevent the generation of Mycoplasma resistance is of great significance.