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目的探讨新疆巴楚县维吾尔族妇女HPV感染、宫颈高级别病变及宫颈癌与血清维生素的关系,为预防及早期诊断提供科学依据。方法 2014年3月1日-6月15日,通过整群抽样的方法,在新疆巴楚县的9个乡镇进行维吾尔族妇女的宫颈癌筛查,共筛查5 045名妇女。选择细胞学ASC-US及以上、care HPV检测阳性或VIA/VILI阳性者646例进入研究队列。选择2011年3月1日-2014年6月15日在新疆医科大学附属肿瘤医院妇科住院确诊的来自巴楚县的宫颈疾病患者187例进入研究队列。检出CIN2+级者作为病例组,慢性宫颈炎及CINⅠ级者作为对照组;HPV感染者作为阳性组,未感染者作为阴性组。研究对象均检测血清维生素的含量,使用care HPV方法检测Human papilloma virus(HPV)感染情况。结果 HPV阳性组与阴性组血清中维生素A、维生素D3、叶酸和和维生素B12的水平差异有统计学意义,而血清中维生素C和维生素E的水平无明显差异。维生素D3≥49.643 4 ng/L是新疆喀什地区巴楚县维吾尔族妇女HPV感染的危险因素,叶酸≥17.670 5 ng/L是新疆喀什地区巴楚县维吾尔族妇女HPV感染的保护因素。病例组血清中维生素C、维生素A和维生素D3的水平有升高的趋势(P均<0.05),而病例组与对照组血清中维生素E、叶酸和维生素B12的水平无明显差异。维生素C≥0.685 7μg/L是新疆喀什地区巴楚县维吾尔族妇女宫颈高级别病变及宫颈癌的保护因素。结论宫颈癌患者血清中叶酸和维生素C的水平在一定范围时对宫颈病变的发生及HPV感染起保护作用,维生素D3是新疆喀什地区巴楚县维吾尔族妇女HPV感染的危险因素.可通过改善妇女维生素的摄入状况,来降低宫颈病变的发生。
Objective To investigate the relationship between HPV infection, high-grade cervical lesions and cervical cancer and serum vitamins in Uygur women in Bachu County, Xinjiang Uygur Autonomous Region, and to provide a scientific basis for prevention and early diagnosis. Methods From March 1 to June 15, 2014, a total of 5 045 women were screened for cervical cancer in Uighur women in 9 townships in Bachu County, Xinjiang by cluster sampling method. Select Cytology ASC-US and above, care HPV test positive or VIA / VILI positive 646 cases were included in the study cohort. Select March 1, 2011 - June 15, 2014 at the Affiliated Tumor Hospital, Xinjiang Medical Gynecology hospitalized patients from Bachu County, 187 cases of cervical disease into the study cohort. CIN2 + was detected as a case group, chronic cervicitis and CIN Ⅰ grade as a control group; HPV-infected patients as a positive group, not infected as a negative group. Subjects were tested for serum vitamin content, using the care HPV method to detect Human papilloma virus (HPV) infection. Results The levels of serum vitamin A, vitamin D3, folic acid and vitamin B12 in HPV positive group and negative group were significantly different, but there was no significant difference in serum vitamin C and vitamin E levels. Vitamin D≥49.643 4 ng / L is a risk factor for HPV infection in Uygur women in Bachu County, Kashi Prefecture, Xinjiang. Folic acid ≥17.670 5 ng / L is a protective factor against Uyghur women with HPV infection in Bachu County, Kashgar region of Xinjiang. Serum levels of vitamin C, vitamin A and vitamin D3 tended to increase (all P <0.05), while serum vitamin E, folic acid and vitamin B12 levels did not differ significantly between cases and controls. Vitamin C≥0.685 7μg / L is a protective factor for cervical high-grade lesions and cervical cancer in Uygur women in Bachu County, Kashgar region of Xinjiang. Conclusion The levels of serum folic acid and vitamin C in cervical cancer patients have a protective effect on the incidence of cervical lesions and HPV infection in a certain range. Vitamin D3 is a risk factor for HPV infection in Uygur women in Bachu County, Kashgar region of Xinjiang. Vitamin intake, to reduce the incidence of cervical lesions.