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目的探讨T2DM患者尿白蛋白排泄率(UAER)与外周血淋巴细胞活化的关系。方法纳入100例T2DM患者,根据UAER水平,分为不伴白蛋白尿(A)组和伴有白蛋白尿(B)组,并设健康对照(C)组,分析UAER与淋巴细胞活化水平和其他指标的相关性。结果 T淋巴细胞HLA-DR抗原阳性(CD3+HLA-DR+)细胞比率A组高于C组[9.7%(6.1%~13.9%)vs 6.2%(4.0%~10.2%),P<0.05]。B淋巴细胞HLA-DR抗原阳性(CD3-HLA-DR+)细胞比率B组低于A组[(15.7±5.7)%vs(18.3±5.2)%,P<0.05]。Spearman相关分析显示,UAER与年龄、病程、SBP及SUA呈正相关,而与CD3-HLA-DR+细胞比率和估算肾小球滤过率(eGFR)呈负相关。结论免疫学异常可能在T2DM患者CKD的病理生理机制发挥一定的作用。
Objective To investigate the relationship between urinary albumin excretion rate (UAER) and peripheral blood lymphocyte activation in T2DM patients. Methods One hundred patients with T2DM were enrolled. According to the level of UAER, they were divided into group without albuminuria (A) and group with albuminuria (B), and healthy control group (C). The levels of UAER and lymphocyte activation Other indicators of relevance. Results The ratio of HLA-DR antigen-positive (CD3 + HLA-DR +) T cells in group A was significantly higher than that in group C [9.7% (6.1% ~ 13.9%) vs 6.2% (4.0% ~ 10.2%), P <0.05]. The ratio of HLA-DR antigen-positive (CD3-HLA-DR +) B cells in B group was lower than that in A group [(15.7 ± 5.7)% vs (18.3 ± 5.2)%, P <0.05]. Spearman correlation analysis showed that UAER was positively correlated with age, course of disease, SBP and SUA, but negatively correlated with CD3-HLA-DR + cell ratio and estimated glomerular filtration rate (eGFR). Conclusion Immunological abnormalities may play a role in the pathophysiological mechanism of CKD in T2DM patients.