目的　探讨肾集合管癌的临床病理特征。方法　对 3例外科治疗的肾集合管癌进行临床、组织学、免疫组化及超微结构观察 ,并结合文献复习。结果　本病发病年龄 35～ 4 2岁 ,临床无特殊症状 ,影像学检查提示肾细胞癌。病理上肿瘤主要位于肾髓质内 ,组织学瘤细胞呈管状、管状乳头状结构 ,胞质透明或颗粒状 ,核大 ,核仁清晰 ,典型的肿瘤细胞呈靴钉样 ,间质纤维增生 ,多量淋巴细胞浸润并有肿瘤旁集合管上皮细胞的异型增生。免疫组化显示CK(AE3)、EMA和vimentin(+) ,CD10、CEA、CK7和CK2 0 (- )。结论　肾集合管癌是一种少见的起源于集合管上皮的恶性肿瘤 ,肿瘤呈管状、乳头状排列 ,细胞呈靴钉状伴间质的纤维增生和炎细胞反应 ,确诊本病时应与肾乳头状癌和肾髓质癌鉴别 Objective To investigate the clinicopathological features of renal tubules. Methods The clinical, histological, immunohistochemical and ultrastructural observations of 3 cases of surgically treated renal aggregate cancer were reviewed and reviewed. Results The disease onset age 35 ~ 4 2 years old, no special clinical symptoms, imaging studies suggest renal cell carcinoma. Pathological tumors are mainly located in the medullary, histological tumor cells were tubular, papillary tubular structure, cytoplasm transparent or granular, large nuclei, clear nucleoli, the typical tumor cells were like nails, interstitial fibrosis, A large number of lymphocytic infiltration and tumor beside the collecting duct epithelial dysplasia. Immunohistochemistry showed CK (AE3), EMA and vimentin (+), CD10, CEA, CK7 and CK20 (-). Conclusions Kidney-collecting ductal carcinoma is a rare malignant tumor originated from the collecting duct epithelium. The tumor is tubular and papillary, and the cells are in the form of bootles with interstitial fibrosis and inflammatory cells. When diagnosed, the disease should be related to the kidney Papillary and renal medullary cancer identification