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A novel type of Fe3O4 nanoparticles modified glass carbon electrode(Fe3O4/GCE) was constructed and the electrochemical properties of N-(4-nitro-2-phenoxyphenyl)methanesulfonamide(nimesulide) were studied on the Fe3O4/GCE.In 0.4mol/L HAc-NaAc buffer solution(pH=5.0),the electrode process of nimesulide was irreversible at bare GCE and Fe3O4/GCE.The Fe3O4/GCE exhibited a remarkable catalytic and enhancement effect on the reduction of nimesulide.The reduction peak potential of nimesulide shifted positively from-0.683 V at bare GCE to-0.625 V at Fe3O4/GCE,and the sensitivity was increased by ca.3 times.Some experimental conditions were optimized.The linear range between the peak current and the concentration of nimesulide was 2.6×10-6 “1.0×10-4mol/L(R=0.993) with a detection limit of 1.3×10-7mol/L.This method has been used to determine the content of nimesulide in medical tablets.The recovery was determined to be 96.9% ”101.9% by means of standard addition method.The method is comparable to UV-Vis spectrometry.
A novel type of Fe3O4 nanoparticles modified glass carbon electrode (Fe3O4 / GCE) was constructed and the electrochemical properties of N- (4-nitro-2-phenoxyphenyl) methanesulfonamide (nimesulide) were studied on the Fe3O4 / GCE.In 0.4 mol / L HAc-NaAc buffer solution (pH = 5.0), the electrode process of nimesulide was irreversible at bare GCE and Fe3O4 / GCE.The Fe3O4 / GCE exhibited a remarkable catalytic and enhancement effect on the reduction of nimesulide. The reduction peak potential of nimesulide shifted positively from-0.683 V at bare GCE to-0.625 V at Fe3O4 / GCE, and the sensitivity was increased by ca.3 times. Some experimental conditions were optimized. The linear range between the peak current and the concentration of nimesulide was 2.6 × 10 -6 “” 1.0 × 10 -4 mol / L (R = 0.993) with a detection limit of 1.3 × 10 -7 mol / L. This method has been used to determine the content of nimesulide in medical tablets. 96.9% "101.9% by means of standard addition method. The method is comparab le to UV-Vis spectrometry.