【摘 要】
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Worldwide, more than 40 million people are afflicted with Alzheimer\'s disease (AD) (Esquerda-Canals et al., 2017). AD is a devastating neurodegenerative disroder characterized by progressive decline in cognitive abilities. A hallmark of AD and other ne
【机 构】
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Mouse Cancer Genetics Program,Center forCancer Research,National Cancer Institute,Frederick,MD,USA
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Worldwide, more than 40 million people are afflicted with Alzheimer\'s disease (AD) (Esquerda-Canals et al., 2017). AD is a devastating neurodegenerative disroder characterized by progressive decline in cognitive abilities. A hallmark of AD and other neurodegenerative disorders in humans is the aggregation of proteins into amyloid fibrils and their deposition into plaques and intracellular inclusions (Iadanza et al., 2018). In AD, following a series of proteolytic cleavage events amyloid precursor proteins give rise to Aβ monomers, which, in turn, assemble into soluble amyloid oligomers (AOs) that ultimately become insoluble mature amyloid fibrils enriched with highly ordered cross β-sheet structures. This entire process is termed as amyloidogenesis (Chen et al., 2017).
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