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将人类鼻咽癌不同克隆株的细胞悬液移植在严重联合免疫缺陷（ＳＣＩＤ）小鼠和ＢＡＬＢ／ｃ（ｕｎ／ｕｎ）裸小鼠的颈背侧皮下，５６ｄ后处死全部动物进行观察。结果发现，在ＳＣＩＤ小鼠体内移植后ＣＮＥ２Ｌ２为高转移克隆株，其淋巴结转移率为１００％，肺转移率为７１％；而ＣＮＥ２Ｌ４为低转移克隆株，其肺转移率为１３％，淋巴结未见癌转移。这是从１个细胞母系中新筛选出的１个高转移和１个低转移的癌细胞克隆株。实验结果还显示，同ＢＡＬＢ／ｃ（ｕｎ／ｕｎ）裸小鼠相比，ＳＣＩＤ小鼠的恶性表型的表达能力高。另外，皮下移植时肿瘤细胞的数量可能与转移表型的表达有相关性，移植的瘤细胞数越多，转移率越高，反之亦然。
Cell suspensions from different clonal strains of human nasopharyngeal carcinoma were transplanted into the dorsal sciatic skin of SCID mice and BALB / c (un / un) nude mice. After 56 days, all the animals were killed for observation. The results showed that CNE2L2 was a highly metastatic clone after SCID transplantation in vivo, with lymph node metastasis rate of 100% and lung metastasis rate of 71%; while CNE2L4 was a low metastatic clone with lung metastasis rate of 13% See cancer metastasis. This is a clone of a highly metastatic and a low metastatic cancer cell line newly screened from one cell line. The experimental results also show that the malignant phenotype of SCID mice is highly expressed compared to BALB / c (un / un) nude mice. In addition, the number of tumor cells when subcutaneously transplanted may be correlated with the expression of the metastatic phenotype. The more the tumor cells are transplanted, the higher the rate of metastasis and vice versa.