【摘 要】
：
目的 探讨前列腺素E2(PGE2)与膀胱过度活动症(OAB)的关系.方法 通过计算机从PubMed、Web of Science、Embase、Cochrane Library、知网和万方数据库中检索建库至2020年4月所有关于PGE2与OAB关系的临床随机对照试验文献资料,由2名研究者独立进行文献筛选、数据提取及文献质量评价,使用Review Manager Version 5.3软件进行Meta分析.结果 共纳入6篇文献.分析结果显示,OAB组患者的尿PGE2水平均明显高于对照组(SMD=3.85,9
【机 构】
：
山西医科大学,太原 030001;山西医科大学第一医院泌尿外科,太原030001
论文部分内容阅读
目的 探讨前列腺素E2(PGE2)与膀胱过度活动症(OAB)的关系.方法 通过计算机从PubMed、Web of Science、Embase、Cochrane Library、知网和万方数据库中检索建库至2020年4月所有关于PGE2与OAB关系的临床随机对照试验文献资料,由2名研究者独立进行文献筛选、数据提取及文献质量评价,使用Review Manager Version 5.3软件进行Meta分析.结果 共纳入6篇文献.分析结果显示,OAB组患者的尿PGE2水平均明显高于对照组(SMD=3.85,95％ CI:0.96～6.74,P=0.009);OAB患者的尿PGE2/Cr水平高于间质性膀胱炎/膀胱疼痛综合征(IC/PBS)患者,差异有统计学意义(SMD =0.39,95％ CI:0.04～0.74,P=0.03).结论 OAB患者尿PGE2水平明显增高,但尿PGE2尚不能作为诊断OAB的潜在生物标志物,也不能作为鉴别OAB和IC/PBS的潜在生物标志物.
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